Rare diseases affect fewer than 1 in 2,000 people individually. However, with over 7,000 different types identified, their global impact is significant. In the Asia-Pacific region, approximately 258 million people have a rare disease, the highest number globally, with over 45 million in Southeast Asia alone. This vast number highlights significant challenges in treatment, as the diversity of this patient pool contributes to significant health care disparities and increased challenges in clinical trial recruitment.